Diabetes and high blood pressure are the biggest leading causes of chronic kidney disease (CKD). Among other factors, autoimmune diseases,salty and unhealthy diets, a lack of regular activity can also cause damage to your kidneys over time.Diabetes and high blood pressure are the biggest leading causes of chronic kidney disease (CKD). a lack of regular activity can also cause damage to your kidneys over time.Diabetes and high blood pressure are the biggest leading causes of chronic kidney disease (CKD).